Effects of Early Enteral Nutrition on Nutritional Status and Immune Function in Colon Cancer Patients During Chemotherapy

Abstract

This study aimed to assess the effects of early enteral nutrition on nutritional status as well as immune function in colon cancer patients undergoing chemotherapy. A cohort of 120 patients, admitted between January 2021 and December 2022, was selected, and divided into two groups using a double-blind random sampling approach. The control group (n = 60) received early parenteral nutrition, while the study group (n = 60) was administered an early enteral nutrition suspension. Both groups underwent conventional chemotherapy. Post-intervention analysis revealed that serum levels of hemoglobin, albumin, prealbumin, immunoglobulin A, G, and M were significantly enhanced in the study group compared to the control group. Conversely, serum levels of interleukin-1, interleukin-8, and tumor necrosis factor-α were reduced. Furthermore, quality of life scores improved in both groups post-intervention, with the study group demonstrating a more pronounced improvement. The study group also exhibited a lower incidence of adverse reactions. In conclusion, early enteral nutrition support in colon cancer patients receiving chemotherapy significantly promoted their nutritional and immune status, reduced the incidence of adverse reactions, and consequently improved their quality of life.