Effects of dutasteride and finasteride on prostate volume and blood in patients undergoing plasma kinetic vaporization operation

Abstract

Objective To compare the effects of dutasteride and finasteride on prostate volume and blood in patients undergoing plasma kinetic vaporization operation, and to provide a basis for clinical application. Methods 98 cases of benign prostatic hyperplasia were selected as the subjects, and were divided into dutasteride group and finasteride group according to the random number table method. Before and after surgery, dutasteride group was treated with oral dutasteride for one week, and finasteride group was treated with oral finasteride for one week. All patients were treated with transurethral resection of prostate by the same surgical group. Evaluated the efficacy and surgical indicators of the two groups. Results Before operation, the maximum blood flow velocity of dutasteride group after one week of medication was lower than that at hospital admission (P<0.05). After operation, the volume of prostate, the maximum blood flow velocity, IPSS score, the levels of hemoglobin and hematocrit were decreased, while the maximum urinary flow rate was increased (P<0.05). After operation, the maximum urinary flow rate of the two groups were increased after one week of medication (P<0.05). The duration of hematuria in the dutasteride group was lower than that in the finasteride group (P<0.05). Conclusions The using of dutasteride and finasteride during the perioperative period have no significant effect on the prostate volume of patients with benign prostatic hyperplasia. However compared with finasteride, dutasteride can improve the maximum urinary flow rate, shorten the postoperative hematuria time, worthy of clinical promotion. Key words: Benign prostatic hyperplasia; Plasma kinetic vaporization operation; Dutasteride; Finasteride