Effects of different doses of naloxone on resuscitation of patients with quality of dezocine anesthesia

Abstract

Objective To analyze the effects of different doses of naloxone on resuscitation of patients with quality of dezocine anesthesia. Methods 84 patients with dezocine anesthesia surgery were selected and divided into three groups in accordance with the use of naloxone plus volume, 28 cases in each group.All patients were treated with vein injection of propofol, fentanyl and Shun type atracurium for induction of anesthesia, endotracheal intubation and mechanical ventilation were given dezocine infusion to maintain anesthesia.After the operation, the high dose group was given 14μg/kg naloxone, the low dose group was given 7μg/kg naloxone, and the control group only received intravenous infusion of the corresponding measurement.Mean arterial pressure (map), heart rate (HR) before anesthesia, recovery, extubation and intubation after 10min of three groups were observed.Pain and sedation situation score of the patients regained consciousness after 1min, 1h, 2h were received by visual analogue scale (VAS), sedation/restlessness score (SAS). At the same time, the incidence of complications and adverse reactions of the three groups were recorded. Results There were no significant differences in MAP and HR indexes among the three groups before anesthesia.At resuscitation and extubation there were no differences in MAP and HR between the low dose group and the control group (all P>0.05). However, resuscitation, extubation, MAP and HR were significantly lower in the low dose group than those in the high dose group (all P<0.05). The difference of VAS, SAS score had no statistical significance between the low dose group waken up each time and control group, but the VAS, SAS score in the high dose group waken up each time were significantly higher than those in the control group and low dose group(all P<0.05). The respiratory inhibition in the high dose group and low dose group were significantly lower than those of the control group(0, 3.57% and 10.71%; χ2=4.169, 1.077, all P<0.05), but nausea and vomiting in the high dose group were higher than those in the control group and low dose group(all P<0.05). Conclusion Different doses of naloxone could be used for patients using dezocine anesthesia according to patients after operation, to reduce respiratory inhibition, and help patients relieve pain and agitation, and the recommend dose of naloxone is 7μg/kg. Key words: Anesthesiology; Dezocine; Naloxone; Recovery; Complications