Effects of different doses of caffeine in the treatment of neonatal apnea

Abstract

Objective To investigate the therapeutic effect of different doses of caffeine on premature apnea. Methods 80 patients with apnea were divided into observation group and control group, each group in 40cases.The two groups applicated caffeine citrate. The control group received the basal dose, first application of 20 mg/kg, intravenous injection, intravenous injection of 5 mg/kg after 24 h. The observation group was treated with intravenous injection of 10 mg/kg after 24 h. The treatment period was 7 d. The therapeutic effect, blood gas and oxygenation index and adverse reactions were observed in the two groups. Results The effective rate of the observation group was 92.5%, which was significantly higher than 75.0% of the control group(χ2=4.501, P 0.05). Conclusion In the treatment of premature apnea, advanced caffeine citrate treatment can better improve the clinical symptoms and blood gas index, the curative effect is reliable. Key words: Apnea; Caffeine; Infant, premature