Effects of different anesthesia on immune function in patients with colorectal cancer radical mastectomy

Abstract

Objective To investigate the effects of different anesthesia methods on immunity in patients underwent radical resection of rectal carcinoma.Methods 82 patients underwent radical resection of rectal carcinoma were divided into two groups,each group had 41 cases.A group received total intravenous anesthesia while B group received total intravenous anesthesia combined with eqidural anesthesia.CD3＋,CD4＋,CD4＋/CD8＋,CD3＋HLA-DR＋and NK cells were inspected before induction of anesthesia（T0）,2 h after skin incision（T1）,2 h（T2） and 24 h（T3） after the end of operation.The T-lymphocyte subsets,activated T cells and NK cells were measured by flow cytometry. Visual analogue scale（VAS） was observed at T2 and T3.Results The VAS score of T2,T3 in A group[（3.86 ± 0.46）points,（3.62 ±0.26）points]were higher than those in B group[（1.67 ±0.57）points,（1.94 ±0.42）points] （all P〈0.05）.The percentages of CD3＋,CD4＋,CD4＋/CD8＋,CD3＋HLA-DR＋and NK cells of T1,T2,T3 were lower than those of T0 in A group（all P〈0.05）;The percentages of CD3＋,CD4＋,CD4＋/CD8＋,CD3＋HLA-DR＋and NK cells of T1, T2 were lower than those of T0 in B group （ all P 〈0.05 ）;The percentages of CD3＋, CD4＋, CD4＋/CD8＋, CD3＋HLA-DR＋ and NK cells of T1, T2, T3 in A group were lower than those in B group （ all P 〈0.05 ）. Conclusion Total intravenous anesthesia combined with eqidural anesthesia produces less immune suppression than total intravenous anesthesia. Key words: Rectal Neoplasms Surgical Procedures; Operative Anesthesia; Epidural Immunity