Abstract
A report is made of three patients in whom there was pulmonary fibrosis with evidence of impairment of gaseous diffusion across the alveolar-capillary membrane. In one case the process was due to scleroderma, in another it was secondary to pulmonary granulomatosis of undetermined etiology and in the third it was of unknown cause. The clinical and physiologic effects of ACTH or cortisone in each patient are presented. The patient with scleroderma was not benefited by therapy. The other two patients were improved, at least temporarily, one strikingly so. Mechanisms of action of these hormones in these patients are discussed.
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