Effects of coronary injection of loading dose of tirofiban hydrochloride in emergency percutaneous coronary intervention of acute STEMI on cardiac function

Abstract

Objective To investigate the effect of coronary injection of loading dose of tirofiban hydrochloride on emergency percutaneous coronary intervention (PCI) of patients with acute ST segment elevation myocardial infarction (STEMI) on cardiac function. Methods Eighty-six patients with STEMI from March 2014 to June 2015 were selected and divided into control group (n=43) and study group (n=43) according to the different treatment schemes.In the control group, PCI was treated with normal saline, and the study group was treated with hydrochloric acid. The postoperative reperfusion indexes [IRA no reflow and creatine kinase isoenzyme (CK-MB) peak, CK-MB peak time, ST segment decline>50.0%, TIMI 3 flow] level, the cardiac function indexes before and after operation[ left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd), left ventricular end diastolic diameter (LVESD)] levels were comparte between the two groups. One year after operation, the patients were followed up, the incidences of adverse cardiovascular events and long-term survival rates of the two groups were statistically analyzed. Results The IRA without complex flow rate (4.65%) and peak CK-MB [(181.06±34.18) U/L], CK-MB peak time [(10.16±1.61) h], ST segment resolution>50.00% rate (93.02%), TIMI 3 flow rate (95.35%) in study group were significantly better than those of the control group, the differences were significant (P 0.05). After treatment, the indexes in the study group were significantly better than those in the control group, the differences were significant (P<0.05); the incidence of adverse cardiovascular events (9.31%) in the study group was significantly lower than that in the control group (30.24%), and the 1 year survival rate (95.35%) was significantly higher than that in the control group (76.74%), and the differences were significant (P<0.05). Conclusions The effect of coronary injection of lodding dose of tirofiban hydrochloride on emergency PCI of patients with acute STEMI is significant, it can effectively improve the myocardial reperfusion and heart function, reduce the incidence of adverse cardiovascular events and improve the prognosis and increase the long-term survival rate. Key words: ST segment elevation myocardial infarction; Percutaneous coronary intervention; Hydrochloride; Cardiac function