Effects of tirofiban on TIMI blood flow and electrocardiogram in patients with ST segment elevation myocardial infarction complicated with arrhythmia underwent emergency percutaneous coronary intervention

Abstract

Objective To study the effects of tirofiban on TIMI blood flow and electrocardiogram in patients with ST segment elevation myocardial infarction complicated with arrhythmia treated by emergency percutaneous coronary intervention (PCI). Methods Sixty-two patients with ST segment elevation myocardial infarction and arrhythmia from January 2013 to July 2016 were selected.Using a random number table method, they were divided into observation group (n=31) and control group (n=31). The two groups were treated by percutaneous coronary intervention, the observation group was treated with tirofiban before treatment, and the control group was treated with clopidogrel and aspirin. Before and after treatment, the TIMI flow grade distribution, electrocardiogram (24 h after treatment of ventricular arrhythmia, the J wave disappeared and Sigma J decline 2 h after treatment), heart function index [left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD)] were compared. Results Comparing with the control group after treatment TIMI blood flow classification, the observation group improved significantly, the difference was significant (P<0.05). In the observation group, 24 h after treatment, the incidence of ventricular arrhythmia was lower than that in the control group, the incidence of J wave disappearance, and ∑J decline 2 h after treatment were higher than those of the control group, the differences were significant (P<0.05). Comparing with the control group after treatment, LVEDD, LVESD were lower, LVEF in the observation group was higher, the differences were significant (P<0.05). Conclusions In patients with ST segment elevation myocardial infarction complicated with arrhythmia emergency percutaneous coronary intervention, can improve the patients’ TIMI blood flow classification, improve the electrocardiogram performance, so it is worth promoting. Key words: TIMI blood flow; Tirofiban; Electrocardiogram; ST segment elevation myocardial infarction with arrhythmia