Effect of Tirofiban on the cardiac function and myocardial perfusion in patients with acute ST segment elevation myocardial infarction with percutaneous coronary intervention

Abstract

Objective To study the effect of Tirofiban on the cardiac function and myocardial perfusion in patients with acute ST segment elevation myocardial infarction with percutaneous coronary intervention. Methods Eighty patients with acute ST segment elevation myocardial infarction needed the treatment of percutaneous coronary intervention from September 2012 to September 2014 were randomly selected and divided into experiment group (36 cases) and control group (44 cases) according to the random number table method. The patients in the control group were given conventional medicine treatment, and the patients in the experiment group were treated with tirofiban hydrochloride based on the routine medicine treatment, then the heart function and myocardial perfusion changes of the two groups were compared. Results Myocardial perfusion: the rate of TM1 3 blood flow ratio after surgery in the experiment group was not significanty different compared with that in the control group(P>0.05), and corrected TM 1 frames, peak value of CK-MB and the rate of RA no reflow ratio were much lower than those in the control group (P 0.05), the incidence of cardiovascular events within 12 months after the operation between the experiment group(2.78%) and the control group (20.45%) was significant different(P<0.05). Conclusions Tirofiban hydrochloride in the treatment of patients with acute ST segment elevation myocardial infarction with percutaneous coronary intervention can reduce myocardial perfusion injury, improve cardiac function, and reduce the incidence of adverse cardiovascular events. Key words: Tirofiban hydrochloride; Percutaneous coronary intervention; Acute ST segment elevation myocardial infarction; Cardiac function; Myocardial perfusion