Effects of compound alpha keto acid combining calcium carbonate D3 on serum levels of ALB and AKP and quality of life in patients undergoing maintenance hemodialysis

Abstract

Objective To investigate the effects of compound alpha keto acid combining calcium carbonate D3 on serum levels of albumin (ALB) and alkaline phosphatase (AKP) and quality of life in patients undergoing maintenance hemodialysis. Methods 87 patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis from December 2014 to March 2017 at our hospital were selected and randomly divided into an observation group (n=44) and a control group (n=43). Both groups were routinely treated with maintenance hemodialysis, 4 h/time, 3 times/week. In addition, the control group were treated with compound alpha keto acid, while the observation group with compound alpha keto acid and calcium carbonate D3. The treatment course was 3 months. The calcium and phosphorus metabolism situation (phosphorus, calcium, and phosphorus products) and serum levels of ALB and AKP, nutritional status (SGA) score, quality of life (SF-36) score, and the incidence of adverse reactions during medication were compared between the two groups before and after the treatment. Results Before the treatment, there were no statistical differences in blood calcium and phosphorus, calcium-phosphorus product, and serum levels of ALB and AKP between the two groups (all P > 0.05). After the treatment, the blood calcium and phosphorus levels, calcium-phosphorus product, and serum levels of ALB and AKP were improved in the two groups (P﹤0.05). There was no statistical difference in serum calcium levels between the two groups (P >0.05). The phosphorus level, calcium-phosphorus product, and AKP were lower and the ALB was higher in the observation group than in the control group (P 0.05). Before the treatment, there were no statistical differences in the scores of SGA and SF-36 between the two groups (P >0.05). The scores of SGA and SF-36 were better after than before the treatment in both groups (P<0.05) and were so in the observation group than in the control group after the treatment (P<0.05). Conclusion Compound alpha keto acid combining calcium carbonate D3 for patients undergoing maintenance hemodialysis is effective and safe and can effectively correct the disorder of calcium and phosphorus metabolism and improve the serum levels of ALB and AKP and the patients’ quality of life. Key words: Maintenance hemodialysis; Compound alpha keto acid; Calcium carbonate; D3; ALB; AKP