Effects of combination therapy of calcium dobesilate dispersible and monosialotetrahex-osylganlioside sodium on serum inflammatory cytokines IL-6 and MCP-1 in elderly patients with painful diabetic peripheral neuropathy

Abstract

Objective To observe the efficacy of combination therapy of calcium dobesilate dispersible and monosialotetrahexosylganlioside sodium on interleukin-6(IL-6) and monocyte chemotactic protein-1(MCP-1) in elderly patients with painful diabetic peripheral neuropathy. Methods From January 2012 to May 2017, in the Second People's Hospital of Lianyungang 70 patients of painful diabetic peripheral neuropathy, aged ≥60 years, were analyzed in this study.They were randomly divided into observation group (35 cases) and control group (35 cases). The observation group was treated with 40mg monosialotetrahexosylganlioside sodium dissolved in 250mL physiological saline, intravenous infusion per day, and oral calcium dobesilate dispersible 0.5g twice a day for two weeks.The control group was treated with methylcobalamin injection 0.5mg per day for two weeks.The clinical treatment effects and levels of IL-6 and MCP-1 were observed and compared between the two groups. Results After two weeks of treatment, the MDNS and MNSI scores of the observation group [(13.09±5.38)points, (2.53±1.19)points]were significantly lower than those of the control group[(18.31±6.13)points, (4.19±1.05)points, t=2.036, 2.365, all P<0.05]and those before treatment[(21.26±4.28)points, (5.40±0.89)points, t=3.251, 3.698, all P<0.05]. The VAS-PI scores in the observation group[(6.24±1.25)points, (4.13±1.69)points]were significantly lower than those in the control group[(7.26±1.28)points, (6.34±2.65)points] at the first and second week(t=3.265, 5.395, all P<0.05). The serum levels of inflammatory cytokines IL-6 and MCP-1 in the observation group [(15.16±0.88) ng/L, (157.19±11.22)ng/L] were significantly lower than those in the control group[(17.87±1.19)ng/L, (198.21±12.07)ng/L, t=2.152, 1.365, all P<0.05]and those before treatment[(20.26±1.05)ng/L, (260.44±13.63)ng/L, t=1.235, 0.965, all P<0.05]. Conclusion Combination of calcium dobesilate and monosialotetrahexosyl ganglioside may alleviate the sensory and pain sensations in patients with painful diabetic peripheral neuropathy, possibly by reducing the level of inflammatory cytokines IL-6 and MCP-1. Key words: Diabetic neuropathies; Interleukin-6; Monocyte chemotactic protein-1; Michigan diabetic neuropathy score; Michigan neuropmhy screening instrument; Calcium dobesilate dispersible; Monosialotetrahexosylganlioside sodium