Effects of Collagen Peptides from Cod (Gadus) Skin on Delaying H2O2-Induced Senescence of 2BS Cells

Abstract

ABSTRACT The purpose of this research was to explore the impact of collagen peptides derived from cod (Gadus) skin on H2O2-induced 2BS senescence cells. The senescence model induced by H2O2 was established to determine the cell proliferation rate, ROS level, cell apoptosis, and peroxidase content after the intervention of the optimal dose of collagen peptides. Collagen peptides effectively suppressed apoptosis in 2BS senescence cells, substantially decreasing ROS and MDA levels. Furthermore, SOD and CAT activities were significantly elevated. In summary, collagen peptides have demonstrated a significant capacity to impede the process of cellular senescence in 2BS cells through the reduction of oxidative stress and apoptosis.