Abstract
1. Aflatoxin B 1, a known hepatocarcinogen, is found to induce polysomal disaggregation in rat liver. 2. The entry of [ 14C]orotic acid into liver RNA is also inhibited by this toxin. A significant inhibition is obtained at a dose as low as 6.5 μg per 100 g body weight and the inhibition seems to be almost complete at 150 μg per 100 g body weight. At lower doses the ribosomal RNA's showed greater susceptibility to inhibition than the smaller RNA species. 3. Aflatoxin B 1 did not inhibit an in vitro RNA synthesizing system containing rat-testicular RNA polymerase (nucleoside triphosphate: RNA nucleotidyltransferase, EC 2.7.7.6). 4. These results suggest that a metabolite of aflatoxin B 1 rather than the toxin itself is a binding inhibitor of DNA-dependent RNA synthesis.
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