Abstract
Objective To investigate the effects of aerosolized Dexamethsone inhalation on circulatory and respiratory function during lung injury (ALI) induced by hydrochloric acid (HCI) aspiration.Methods Twenty-four healthy pigs of either sex,weighting (15.5±2) kg were anesthetized with intraperitoneal injection of pentobarbital sodium 50mg/kg and intubated and mechanically ventilated (FiO2=1.0,VT=10-15 ml/kg,RR=16bpm,I:E=1:2).Anesthesia was maintained with infusion of Ketamine,procaine and succinylcholine.Femoral artery was cannulated for MAP monitoring and blood sampling.Swan-Ganz catheter was placed in the pulmonary artery via right inexternal jugular vein.Dilute HC1 (0.1mol/L) was instilled via trachea into lungs until PaO2 was＜13.3kPa.Arterial blood gases,MAP,MPAP and dynamic compliance were measured before induction of ALl (T0),when ALI was induced (T1) and 1,2,3 and 4(T2～5)there after.The pigs were then divided randomly into three groups according to the treatment they received:group A received IPPV alone,group B IPPV+PEEP(0.69kPa) ,group C IPPV+PEEP(0.69kPa)+aerosolized Dexamethasone (12.5ugokg-loh-I).Results MAP decreased significantly after induction of ALI in three groups hut there was no significant difference in MAP among the three groups (P＞0.05).MPAP increased significantly after induction of ALI in all groups and remained high during the period of T2～5 in group A and B (P＞0.05),hut decreased significantly from T2 in group C (P＜0.05 ).PaO2 increased significantly during the treatment in group B、C(P＜0.05),and was significantly higher in group C than that in group B (P＜0.05).PaCO2 in group A was highest in three groups (P＜0.05) and group C was lower in three groups (P＜0.05).Dynamic lung compliance decreased in all animals after induction of lung injury (P＞0.05),but was gradually increasing significantly during treatment(B、C group) (P＜0.05).Conclusion Aerosolized Dexamethasone inhalation can improve respiratory function during ALI induced by HC1 aspiration and reduce pulmonary hypertension,but dont impair MAP.Both have the same effects on the treatment of lung injuries. Key words: Dexamethasone; Respiratory distres syndrome,adult; Administration,inhalation; Swine
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
