Abstract
Abstract 5'-Deoxyadenosine inhibits purine ribonucleotide synthesis de novo , as well as synthesis from adenine, guanine and hypoxanthine in Ehrlich ascites tumor cells in vitro . This is due to inhibition of the synthesis of phosphoribosyl pyrophosphate, but phosphoribosyl pyrophosphate synthetase itself is not inhibited. 5'-Deoxyadenosine affects several aspects of glucose metabolism, and it is proposed that this leads, in an as yet unknown way, to a decreased availability of ribose 5-phosphate for phosphoribosyl pyrophosphate synthesis.
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