Abstract
Objective To observe the effects of warm water bath active rewarming and passive rewarming on lung pathological injury and arterial blood gas of SD rats with hypothermia induced by prolonged seawater immersion. Methods One hundred male Sprague-Dawley rats were randomly divided into the normal control group (without any treatment) and the hypothermia group (seawater immersion at 20 ℃ for 24 h), The animals in the passive rewarming groups 1, 2, 3 and 4, each consisting of 10, had seawater immersion at 20 ℃ for 24 h and received passive rewarming, and then they were respectively executed at 0, 3, 6 and 12 hours after rewarming, The animals in the active rewarming groups 1, 2, 3 and 4, each consisting of 10, underwent seawater immersion at 20 ℃ for 24 h and received active rewarming, and then they were sacrificed at 0, 3, 6 and 12 hours after rewarming, Changes in lung pathology, arterial blood gas and other indicators were detected in all the animal groups. Results Both warm water bath active rewarming and passive rewarming all could help to restore lung injury and blood gas abnormality in rats with hypothermia induced by prolonged seawater immersion. Compared with that of the passive rewarming group[6 h: (7.6±2.2) scores, 12 h: (5.3±1.3) scores], the recovery of lung pathological injury in warm water bath rewarming group was obviously better at 6 h(5.8±1.2) scores and 12 h(3.8±1.4) scores after rewarming, with statistical significance (P<0.05), and actual bicarbonate recovery was even better at 6 h after rewarming, also with statistical significance (P<0.05). Conclusions Compared with passive rewarming, warm water bath rewarming could significantly alleviate lung injury and arterial blood gas abnormality in hypothermic rats induced by prolonged seawater immersion, and it might produce even better effect on the prevention of rewarming-related acute respiratory distress syndrome. Key words: Seawater immersion; Hypothermia; SD rat; Warm water bath rewarming; Passive rewarming; Lung injury; Blood gas analysis
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call