Effect of Zhenwu decoction in the treatment of acute heart failure and its influence on cardiac function, cardiomyocyte apoptosis factor and serum level of brain natriuretic peptide

Abstract

Objective To explore the clinical effect of Zhenwu decoction in the treatment of acute heart failure(AHF), and its influence on cardiac function, cardiomyocyte apoptosis factor and serum level of brain natriuretic peptide(BNP). Methods 94 patients with AHF were enrolled in the study.According to their treatment time number, 47 cases with odd numbers were selected as control group, who were given west medicine for treatment, while 47 cases with even numbers were selected as observation group, who were given Zhenwu decoction on the basis of control group.The clinical treatment effect of the two groups was evaluated, and the levels of BNP, soluble Fas(sFas), soluble Fas ligand (sFasL), tumor necrosis factor-α(TNF-α), and cardiac function indicators including left ventricular ejection fraction(LVEF), stroke volume(SV), left ventricular end diastole(LVEDd), left ventricular end of systolic diameter(LVEDs) before and after treatment were compared. Results The total effective rate of the observation group was 91.49%(43/47), which was higher than that of the control group 65.96%(31/47), the difference between the two groups was statistically significant(χ2=8.871, P<0.05). After treatment, the LVEF and SV in the observation group were (52.77±4.41)% and (79.00±6.54)mL, respectively, which were higher than those in the control group[(43.15±3.88)%, (69.22±4.80)mL], while the LVEDd and LVEDs of the observation group were (50.55±3.43)mm, (37.44±2.73)mm, respectively, which were lower than those of the control group[(59.52±4.02)mm, (42.04±3.20)mm], the differences were statistically significant(t=7.454, 7.042, 6.768, 6.890, all P<0.05). After treatment, the levels of sFas, sFasL and TNF-α in the observation group were (2.65±0.30)μg/L, (0.21±0.08)μg/L, (1.20±0.13)ng/L, respectively, which were lower than those of the control group[(3.38±0.37)μg/L, (0.33±0.12)μg/L, (1.48±0.20)ng/L], the differences were statistically significant(t=6.438, 6.703, 6.185, all P<0.05). After treatment, the BNP level in the observation group was (252.77±27.43)ng/L, which was lower than that in the control group[(387.67±41.97)ng/L], the difference was statistically significant(t=6.870, P<0.05). Conclusion The curative effect of routine treatment of western medicine combined with Zhenwu decoction in the treatment of AHF is exact, which can significantly improve the clinical symptoms and cardiac function, reduce myocardial cell apoptosis and BNP level, and it has high clinical value, which is worthy of popularization and application. Key words: Heart failure; Zhenwu Decoction; Cardiac function; Cardiomyocyte apoptosis factor; Natriuretic peptide, brain