Abstract
目的 评价大麻素(WIN55,212-2)滴眼液在卡波姆诱导的兔慢性高眼压模型中的降压作用.方法 人工诱导兔慢性高眼压模型.取右眼高眼压兔24只,随机分为A、B、C 3个组,每组8只.右眼结膜囊内分别滴入0.125%大麻素滴眼液、0.5%噻吗心胺滴眼液及生理盐水,用药后每日测眼压1次.任选8只左眼为D组作空白对照.结果 用药1周后眼压大麻素组为用药前的69%,噻吗心胺组为78%;用药3周后眼压大麻素组为用药前的45%,噻吗心胺组为60%.各组间最大降眼压幅度差异有统计学意义(P＜0.01).结论 0.125%大麻素滴眼液点眼降眼压作用确定,与0.5%噻吗心胺比较,持续时间长,下降幅度大。
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