Abstract
Aim The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH). Methods Ten T2D patients (age: 53.6 ± 1.3 years; body mass index: 30.6 ± 1.0 kg/m 2; resting blood glucose: 157.8 ± 40.2 mg dL −1) and 10 non-diabetic (ND) volunteers (age: 47.5 ± 1.0 years; body mass index: 28.3 ± 0.9 kg/m 2; resting blood glucose: 91.2 ± 10.5 mg dL −1) underwent two experimental sessions, consisting of 20 min of rest plus 20 min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3AC1-1 monitor) and PKA were measured during rest and every 15 min for 135 min of the postexercise recovery period (RP). Results During the RP, the ND individuals presented with PEH at 30, 45 and 120 min ( P < 0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15 min postexercise in the ND ( P < 0.05), but not in the T2D patients. Conclusion T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH.
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