122-OR: Profile of Type 2 Diabetes (T2D) Donors in the Integrated Islet Distribution Program (IIDP)

Abstract

The IIDP has been supplying isolated human islets and corresponding data from nondiabetic (ND) donors to diabetes researchers for > 15 years. Since 2010 IIDP also has offered islets from T2D donors, with up to 68% of IIDP researchers interested in receiving them. From 2010-19, this unique desirable resource comprised 7.3% of IIDP isolations (98/1,333). Analysis of ND vs. T2D donor demographics showed similar trends (p=0.94) by sex (M/F ratio 1.37 vs. 1.39, respectively). Donor race/ethnicity differed significantly (p<0.001), with a higher rate of Hispanic in T2D (White: ND 64.0%, T2D 43.9%; Hispanic: ND 20.5%, T2D 40.8%; Black: ND 11.1%, T2D 13.3%; Other [Asian, Hawaiian, Native American]: ND 4.4%, T2D 2.0%). This finding is in line with CDC data that Hispanics are more likely to develop T2D. Median donor age differed significantly (p<0.001), with a median of 46 yrs in ND (range: 4-73) vs. 53 yrs in T2D (range: 26-69). Body Mass Index (BMI) was significantly higher for T2D donors (p<0.001), with ND median of 29.2 (range: 11.8- 64.8) vs. 32.5 for T2D (range: 20.7-50.0). Cause of Death (COD) also differed significantly (p=0.003), with a higher rate of stroke for T2D (50.1% for ND vs. 68.4% in T2D), and higher head trauma in ND (31.2% ND vs. 13.3% T2D); other COD was 18% for both donor types. This difference is likely due to higher cardiovascular disease among T2D Americans. While median total islet equivalents (IEQ) yield was significantly higher (p=0.017) for ND donors (ND median IEQ: 278,792, range 35,000-1,015,455 vs. T2D median IEQ: 221,734, range 50,000-1,032,212), this difference was not as great as expected. A previous IIDP publication showed COD and BMI can affect islet yield. Evaluating the difference in yield between ND and T2D remained significant (p=0.02) after adjusting for these factors, with BMI category being a significant covariate, while COD was not significant in this relatively small sample. Perhaps as our sample of these unique donors grows additional associations with islet yield may emerge. Disclosure B.J. Olack: None. J. Kilburn: None. J.J. Chuang: None. J. Cravens: None. J.C. Niland: None. Funding 2UC4DK098085-02