Effect of tranexamic acid on postoperative blood loss

Abstract

ObjectiveThe aim of this article was to evaluate the efficacy of tranexamic acid (TXA) on reducing the blood loss after maxillofacial fracture surgeries. MethodsClinical data were collected retrospectively from patients with unilateral zygomaticomaxillary complex (ZMC) fracture or unilateral mandibular condylar fracture. Patients were further divided into TXA group and control group according to whether TXA was used or not after surgery. The amount of postoperative blood loss was evaluated by negative pressure drainage volume. Data was statistically analyzed. ResultsFor patients with unilateral ZMC fracture, the total postoperative blood loss in the TXA group was about 30 ml less than that in the control group (p=0.006). It was significantly less on the first and second postoperative days. However, for patients with unilateral mandibular condylar fracture, there was no significant difference between the TXA and control groups (p=0.917). ConclusionTXA can reduce postoperative bleeding in patients with ZMC fracture, and the optimal usage time is on the first and second postoperative days. For patients with mandibular condylar fracture, TXA may not be used.