Effect of Titanium Dioxide Nanoparticles on the Histology of Liver of White Male Rats

Abstract

Background: Nanotechnology or nanoscience considers as a new field of science which has an effective role in the day to day life aspects. This field deals with the production, processing, and use of materials ranging in nanometers. Recently, this field becomes a confederate science that is usually used in other fields of science, like electronics, physics, and engineering. Materials and methods: Study design starts with the choice of nanoparticles (NPs) [titanium dioxide nanoparticles (TiO2)]. Eighteen white male rats were used in this research. Study groups classified into six groups (each group includes three animals): two control groups (for oral and i.p. administration) and four treatment groups (group I: treated with 400 mg/kg orally and i.p., group II: treated with 150 mg/kg orally and i.p.). Results and discussion: Results of this research include the presence of some inflammatory cells infiltration (lymphocyte infiltration), as it showed in the figures of the histological sections of the treated groups compared with the control group. These results were found to be different than studies of other researches that refer to the presence of many undesired hepatic histological and biochemical changes, such as, the effects on membrane structure, oxidative stress, binding protein, or DNA, cell death or apoptosis, and hepatocytes necrosis. Conclusion: In conclusion, Tio2 induce lymphocyte infiltration, but there are no additional deleterious histological changes in the liver tissue.