Abstract
ObjectiveThe aims of this study were to investigate the association between the +781C/T polymorphism of interleukin-8 (IL-8) and atherosclerotic cerebral infarction and the interaction between the +781C/T polymorphism and smoking or drinking in cerebral infarction in the Han Chinese population.MethodsWe investigated the +781C/T polymorphism of IL-8 in 308 consecutive Han Chinese patients who were diagnosed with atherosclerotic cerebral infarction and in 294 age- and gender-matched healthy control subjects. The patients were classified using the Oxfordshire Community Stroke Project (OCSP) classification. The patients and subjects’ histories of smoking and drinking were recorded, and atherosclerosis (AS) of the internal carotid artery (ICA) was evaluated in the patients. The +781C/T polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.ResultsThe +781C/T polymorphism and allele frequencies were not significantly different between the patients and controls and were not significantly associated with the OCSP classifications. We found that the 781C allele was significantly associated with AS of the ICA in the patients (p = 0.017), and the CT genotype was more prevalent in patients without AS of the ICA (p = 0.035). No interactions were observed between the +781C/T polymorphism and smoking or drinking.ConclusionOur results demonstrated that the +781C/T polymorphism of IL-8 did not play a role and had no interaction with smoking or drinking in the occurrence of cerebral infarction in the Han Chinese population. However, the C allele and the CT genotype might be associated with AS of the ICA in patients with ischemic stroke.
Highlights
Cerebrovascular diseases have become the most common cause of death in China [1]
The IL-8 mRNA levels expressed in peripheral blood mononuclear cells (PBMC) has been shown to increase rapidly during the acute stage of cerebral infarction [29]
No previous study has investigated the association of the +781C/T polymorphism with atherosclerotic cerebral infarction, especially in the Han Chinese population
Summary
Cerebrovascular diseases have become the most common cause of death in China [1]. Atherosclerotic cerebral infarction is the most common form of stroke. Many studies have indicated that inflammation plays an important role in the formation of atherosclerosis and ischemic brain injury. As a strong mediator of inflammation, IL-8 plays an important role in promoting the formation of atherosclerosis (AS) [2] and is involved in the process of brain injury after acute cerebral infarction [3,4,5]. Many studies have indicated that genetic polymorphisms were associated with the occurrence of cerebral infarction [6]. A previous study suggested that the +781C/T polymorphism might play a more important role than other SNPs of IL-8, such as -251A/T (rs4073), 1633C/T and 2767A/T, in the transcriptional level of IL-8, which associated strongly with asthma occurrence [13]
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