Abstract
Background: The aim of this study was to investigate the association between the +781C/T polymorphism in the inter leukin-8 (IL-8) gene and the acute neurological recovery and 3-month outcome of atherosclerotic cerebral infarction patients in the Han Chinese population. Methods: We investigated the +781C/T polymorphism of IL-8 in 308 consecutive Han Chinese patients who were diagnosed with an atherosclerotic cerebral infarction. The neurological recovery of the patients were evaluated by the difference of National Institute of Health Stroke Scale (NIHSS) score for the acute stage of the stroke and the Barthel Index (BI) score at 3 months after the stroke. Polymorphic genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: We found that the +781C/T genotypes of IL-8 were significantly associated with neurological recovery after cerebral infarction (p = 0.045), and a significant difference in the neurological recovery of the patients was found between patients with the CT genotype and TT genotype (mean difference: 2.934, p = 0.040). No statistically significant association was found between the +781C/T polymorphism with the 3-month BI scores obtained after cerebral infarction (p = 0.416). Conclusion: Our results demonstrated that the +781C/T polymorphism of IL-8 is associated with neurological recovery at the acute stage of atherosclerotic cerebral infarction in the Han Chinese population, and the patients with the CT genotype recovered better than those with other genotypes. However, no association was found between the +781C/T polymorphism and the 3-month outcome of cerebral infarction patients.
Highlights
Stroke is currently the third cause of death and loss of disability-adjusted life-years (DALYs) in the world [1,2,3], and cerebral infarction is the most common form of stroke
Our results demonstrated that the +781C/T polymorphism of IL-8 is associated with neurological recovery at the acute stage of atherosclerotic cerebral infarction in the Han Chinese population, and the patients with the CT genotype recovered better than those with other genotypes
We found that the +781C/T genotypes of IL-8 were significantly associated with neurological recovery of cerebral infarction (p = 0.045)
Summary
Stroke is currently the third cause of death and loss of disability-adjusted life-years (DALYs) in the world [1,2,3], and cerebral infarction is the most common form of stroke. The IL-8 mRNA levels in peripheral blood mononuclear cells (PBMC) and the IL-8 concentrations in the plasma of patients with acute cerebral infarction have been shown to increase rapidly; these increased levels lasted 20 to 31 days after the stroke and were inversely correlated with neurologic impairment scores [14, 16,17,18]. Taken together, these findings demonstrate that IL-8 affects neurological recovery at the acute stage and the long-term outcome of patients after cerebral infarction. The aim of this study was to investigate the association between the +781C/T polymorphism in the interleukin-8 (IL-8) gene and the acute neurological recovery and 3-month outcome of atherosclerotic cerebral infarction patients in the Han Chinese population
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