Abstract
Purpose: The aim of this study was to compare the efficacy of the Farnsworth D-15 hue test in detecting early ethambutol toxicity compared to the Ishihara pseudoisochromatic plates.
Highlights
Tuberculosis remains an important infectious disease in Hong Kong Special Administrative Region, China
On Ishihara pseudoisochromatic plates testing, all (100%) of the subjects had normal results
The Farnsworth D-15 hue test appears to be more sensitive than the Ishihara pseudoisochromatic plates in detecting colour defects as an initial subjective screening tool for suspected ethambutol-related optic neuropathy
Summary
Tuberculosis remains an important infectious disease in Hong Kong Special Administrative Region, China. The drug has been well associated with ocular toxicity manifesting as optic neuropathy since its first use in the 1960’s[3,4]. Ethambutolinduced optic neuropathy is duration and dose dependent, rare cases of idiosyncratic reaction presenting days after the commencement of a standard dose have been re-. The reported incidence of toxicity is 18% in those with a daily dose > 35 mg/kg, 5-6% in those with 25 mg/kg, and approximately 1% with a daily dose of 15 mg/kg for 2 months or more[4,8,9]. In Hong Kong, the standard daily dose is mg/kg for the treatment of pulmonary tuberculosis. At this dosage, toxic optic neuropathy is uncommon
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