Association between chemokine CXC ligand 16 gene rs2277680 polymorphisms and atherosclerotic acute cerebral infarction

Abstract

Objective To investigate the association between chemokine CXC ligand 16 (CXCL16) gene rs2277680 polymorphism and atherosclerotic acute cerebral infarction (ACI) in Chinese Han population. Methods Four hundred and twenty patients with acute ACI, admitted to our hospital from September 2013 to March 2015, and 268 healthy controls were included in the study. And polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the rs2277680 polymorphisms in the CXCL16 gene. Results The distribution of rs2277680 between the two groups was significantly different at both genotypic level (AA+GA vs. GG=87.9% vs. 82.1%, χ2= 4.418, P=0.036) and allelic level (A vs. G=69.5% vs. 63.1%, χ2=6.184, P=0.013). The AA+GA genotype was an independent risk factor for ACI (OR=2.050, P=0.043, 95% CI: 1.021-4.113). Conclusion The rs2277680 polymorphism of CXCL16 gene is associated with atherosclerotic cerebral infarction in Chinese Han population; the A allele might be a genetic susceptibility gene which leads to ACI. Key words: CXC ligand 16; Atherosclerosis; Cerebral infarction; Polymorphism