Relationship between polymorphisms of lecithin cholesterol acyltransferme gene 608C/T or 511C/T and stroke in Chinese Han population in Hunan province

Abstract

Objective To explore the relationship between lecithin cholesterol acy ltransferase （LCAT） gene 608C/T and 511C/T polymorphisms and stroke in Chinese Han population in Hunan province. Methods One hundred fifty patients with cerebral infarction, 150 patients with cerebral hemorrhage, and 122 age- and sex-matched healthy controls were selected. LCAT gene 608C/T and 511C/T polymorphisms were detected by using polymerase chain reaction, single strand conformation polymorphism, and restriction fragment length polymorphisms. Results The CT genotype frequency （14. 0% ） and T allele frequency （7. 0% ） of the LCAT gene 608C/T in the cerebral infarction group were significantly higher than those in the control group （all P 〈0. 05）, while there were no significant differences in the CT geotype frequency （7. 3% ） and T allele frequency （3.7%） between the cerebral hemorrhage group and the control group （P〉0. 05）. The CT genotype frequency （10. 0%） and T allele frequency （5.0%） of the LCAT gene 511C/T in the cerebral infarction group were significantly higher than those in the control group （all P 〈0. 01）, while there were no significant differences in the CT genotype frequency （3.3%） and T allele frequency （1.7%） between the cerebral hemorrhage group and the control group （P 〉0. 05）. Conclusions The 608C/T and 511CFF polymorphisms may be associated with the occurrence of atherosclerotic cerebral infarction in Chinese Han population in Hunan province. They may be the predisposing factors for atherosclerotic cerebral infarction in this population; however, they are not associated with cerebral hemorrhage. Key words: Phosphatidylcholine-Sterol O-Acyltransferase; Stroke; Brain infarction; Cerebral hemorrhage; Atherosclerosis; Polymorphism, genetic