Abstract
Considering that changes at maternal environment have been associated to important abnormalities at the newborn, the aim of the present study was to examine the impact of sleep restriction during pregnancy on renal morphology and function in young offspring. Female 3 month-old Wistar rats were divided in three experimental groups: C (control), SR (sleep restriction between the 14th and 20th day of pregnancy) and SRT (sleep restriction during all the pregnancy). SR and SRT females were subjected to sleep restriction by the multiple platform technique for 20 hours daily. After birth, the offspring was reduced to 6 male litters per mother. The groups were designated OC (Control's offspring), OSR (SR's offspring) and OSRT (SRT's offspring). Blood pressure (BP) was measured by tail pletismography, at 2 and 3 months of age. Renal function parameters [renal plasma flow (RPF), glomerular filtration rate (GFR), sodium and potassium excretion and proteinuria] were studied at 3 months of age. Increased values of BP were observed in OSR and OSRT in comparison to OC [OSR:145±1.4 (43); OSRT:144±0.9 (68); OC:120±1.0 (45) mmHg, values measured at 3 months]. These groups also showed significant changes in RPF and GFR. Proteinuria was also increased in ORST in comparison to OC. Our present data suggest that changes at the maternal environment due to sleep restriction can result in hypertension and renal dysfunction in young offspring. Financial support: CNPq and FAPESP
Published Version
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