Abstract
906 A number of cross-sectional and longitudinal studies have reported declines in renal function and maximal aerobic capacity (VO2max) with age. The present study was undertaken to test whether aerobic exercise training would improve renal function in older, sedentary hypertensives. Renal plasma flow(RPF) and glomerular filtration rate (GFR) were determined by plasma and urinary clearances of 131I-hippuran and 99mTc-DTPA, respectively, before and after 6 months of aerobic exercise training @70% VO2max) in 16 older (62±2 yrs: mean±SEM) sedentary, hypertensive (165±3/81±2 mm Hg) individuals. Following 6 months of aerobic exercise training there was a significant increase in VO2max(18.0±1.0 vs. 20.4±1.1 ml/kg/min, P=0.0004). However, as a group there were no significant changes in RPF (227±14 vs. 229±15 ml/min/1.73m2, P=0.88), GFR (75±6 vs. 74±7 ml/min/1.73m2, P=0.87) or the calculated (GFR/RPF), glomerular filtration fraction (FF: 0.34±0.03 vs. 0.35±0.04, P=0.88). When the change in VO2max was related to the change in measures of renal function, there were inverse relationships between the change in VO2max and changes in GFR (r=-0.41, P=0.11) and FF (r=-0.56, P=0.02). In addition, there was a significant positive relationship between the change in VO2max and the change in RPF (r=0.58, P=0.02). These data, suggest that improvements in renal function with training in older individuals are dependent upon the improvement in VO2max. We hypothesize that the age-associated decline in renal function is attenuated by aerobic exercise training. FigureFigure
Published Version
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