Abstract
Objective To study the clinical curative effect of Chinese traditional medicine Prunella vulgaris Decoction for elderly hypertensive patients, and its influence on endothelin-1(ET-1). Methods From January 2016 to January 2018, 76 senile patients with hypertension in Wenling Hospital of Traditional Chinese Medicine were selected.According to different therapeutic methods, the patients were divided into two groups, with 38 cases in each group.The control group was given calcium antagonists benzene sulfonic acid amlodipine therapy, the observation group was given the combined therapy of Chinese and western medicine (Prunella vulgaris Decoction combined with benzene sulfonic acid amlodipine). All the patients were treated for 2 months, the therapeutic effect was evaluated.The 24-hour average diastolic blood pressure (24hDBP), 24-hour average systolic blood pressure (24hSBP), and diastolic pressure (dDBP), the day systolic blood pressure (dSBP), diastolic blood pressure at night (nDBP) and nocturnal systolic blood pressure (nSBP) were used to evaluate the clinical curative effect.Before and after treatment, the plasma ET-1 level was used to evaluate the influence on endothelial function.The clinical curative effect and its influence on ET-1 were compared between the two groups. Results After treatment, the 24hDBP, 24hSBP, dDBP, dSBP, nDBP and nSBP in the observation group were significantly lower than those in the control group[24hDBP (72.26±4.62)mmHg vs.(86.63±5.18)mmHg, 24hSBP (133.26±6.71)mmHg vs.(143.29±7.22)mmHg, dDBP (76.08±5.26)mmHg vs.(87.32±5.73)mmHg, dSBP (136.51±8.63)mmHg vs.(153.67±9.51)mmHg, nDBP (72.34±3.96)mmHg vs.(80.75±4.27)mmHg, nSBP (133.64±5.21)mmHg vs.(148.27±6.32)mmHg, t=12.637, 11.268, 11.762, 12.406, 10.625, 11.738, all P<0.05]. The plasma ET-1 level of the observation group was (59.37±7.82)μg/L, which was significantly lower than (67.58±7.72)μg/L of the control group (t=10.653, P<0.05). Conclusion Prunella vulgaris Decoction in the treatment of elderly hypertensive patients can effectively improve therapeutic effect, lower the blood pressure levels, and can improve endothelial function, it is worthy of popularization and application. Key words: Hypertension; Drugs, Chinese herbal; Selfheal soup; Endostatins; Aged
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