Effect of saline nasal irrigation with different temperature on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis

Abstract

Objective:To study the effect of nasal spray on the clinical symptoms and the level of inflammatory factors in patients with allergic rhinitis by salines with different temperature normal salines.Method:One hundred and twenty patients were divided into control group (n = 60) and experimental group (n = 60) randomly and all the patients were given specific immunotherapy. The patients in control group were treated with saline in 25 degrees for nasal douche, while the patients in the experimental group were treated with saline in 40 degrees. Clinical symptoms and inflammatory factors were compared between two groups.Result:In the experimental group, the total effective rate was 95.00%, while the control group was only 76.67%. The difference was statistically significant (P< 0.05). Before treatment, the symptoms scores of nasal congestion, runny nose, nasal itching, sneezing and other symptoms were similar in two groups (P>0.05). After treatment, nasal congestion and sneezing score in experimental group was lower than that in the control group (P< 0.05). The scores of runny nose and nasal itching score is similar in two groups (P> 0.05). Before treatment, the histamine and eosinophil cationic protein (ECP), leukotriene C4 and specific IgE inflammatory factor level were similar in two groups (P> 0.05). After treatment, histamine and leukotriene C4 levels in experimental group is lower than that in the control group (P< 0.05).Conclusion:Forty degrees saline nasal irrigation can reduce histamine and leukotriene C4 level in patient with allergic rhinitis, improving the symptoms of nasal congestion and sneezing.