Clinical efficacy of Qianlie Shutong capsule combined with tamsulosin hydrochloride capsule on inflammatory factors in patients with chronic nonbacterial prostatitis

Abstract

Objective To explore the clinical efficacy of Qianlie Shutong capsule combined with tamsulosin hydrochloride capsule on inflammatory factors in patients with chronic non-bacterial prostatitis. Methods A total of 130 patients with chronic non-bacterial prostatitis were selected from June 2014 to June 2016 in our hospital. A randomized, controlled, double-blind clinical trial was performed according to clinical epidemiological and statistical studies. All patients were randomly divided into two groups: the experimental group (65 cases) and the control group(65 cases). The basic clinical data were recorded (age, BMI, course of disease, etc). The patients in experimental group were treated with Qianlie Shutong capsule and tamsulosin hydrochloride capsule and the patients in control group were treated with tamsulosin hydrochloride capsule. One month as a course of treatment and all patients were treated two courses continuously. Whether there were significant differences in efficiency and incidence of adverse reactions, NIH-CPSI score and IIEF-5 score, maximum urinary flow rate, EPS-WBC, PH value and inflammatory factor were observed between the two groups before and after treatment. Results There were no significant differences between the two groups in the basic clinical data, NIH-CPSI and IIEF-5 scores, maximum urinary flow rate and inflammatory factor levels before treatment (P>0.05). The levels of NIH-CPSI, EPS-WBC, PH value and inflammatory factors in the two groups were significantly lower than those before treatment (P<0.05), and the difference between the two groups was significant (P<0.05 ). The scores of IIEF-5 and the maximum urinary flow rate of the two groups were significantly higher than those before treatment (P<0.05), and the experimental group was more significant than the control group (P<0.05). The total effective rate was 90.80% in the experimental group, 17 cases were cured, 23 cases were markedly effective, 19 cases were effective, 6 cases ineffective. The total effective rate was 73.85% in the control group, 10 cases were cured, 21 cases were markedly effective, 17 cases were effective, 17 cases ineffective, the difference was significant (P<0.05). There was no adverse reaction in the two groups during the course of treatment. Conclusions The clinical effect of Qianlie Shutong capsules combined with tamsulosin hydrochloride capsule in the treatment of chronic non-bacterial prostatitis is more obvious than that of the simple use of tamsulosin hydrochloride capsule, and can effectively reduce the level of inflammatory factors in prostatic fluid. Therefore, the combination procedure should be promoted in clinic. Key words: Prostatitis; Capsules