Effect of residual renal function on quality of life of patients with uremic peritoneal dialysis

Abstract

Objective To explore the effect of residual renal function(RRF) on the quality of life in uremia patients with peritoneal dialysis (PD). Methods 64 patients with uremia who underwent PD for 3 months or more were selected.According to the residual glomerular filtration rate(rGFR), the patients were divided into RRF group[35 cases with rGFR≥1mL· min-1·(1.73m2)-1] and non-RRF group[29 cases with rGFR≤1mL· min-1 ·(1.73m2) -1]. The patients were followed up at 3-month intervals.The quality of life was assessed using the SF-36. Results The calcium, phosphorus, parathyroid hormone, serum creatinine, C-reactive protein, serum albumin, total urea removal, serum potassium, total urea clearance in the non-RRF group were (2.29±0.25)mmol/L, (1.68±0.42)mmol/L, 275.68 ng/L, (1 121.58±215.36)μmol/L, (11.02±14.35)mg/L, (31.01±3.26)g/L, (100±50)mL/d, (3.48±0.78)mmol/L, (1.71±0.28), respectively, which in the RRF group were (2.21±0.19)mmol/L, (1.59±0.35)mmol/L, 147.43ng/L, (872.56±264.68) μmol/L, (5.34±8.97)mg/L, (3.43±0.59)mmol/L, (33.21±4.62)g/L, (5.34±8.97)mg/L, (33.21±4.62) g/L, (800±200)mL/d, (3.79±0.59) mmol/L, (2.01±0.41), respectively, the differences between the two groups were significant (t=2.316, 2.149, 2.353, 3.881, 2.229, 7.213, 2.243, 2.212, 4745, all P 0.05). Univariate linear regression analysis showed that rGFR was not associated with SF-36 overall score.Multivariate linear regression analysis found that SF-36 overall score and serum calcium, phosphorus, parathyroid hormone, serum creatinine, C-reactive protein, peritoneal ultrafiltration volume had relevance(t=4.102, 2.412, 2.174, 4.259). Conclusion There was no significant difference in overall quality of life scores and mental health scores between the RRF group and the non-RRF group.RRF was not directly related to the quality of life of the patients. Key words: Uremia; Peritoneal dialysis; Quality of life