Effect of psychological intervention combined with venlafaxine and risperidone in the treatment of refractory depression and its influence on the quality of life

Abstract

Objective To investigate the effect of psychological intervention combined with venlafaxine and risperidone in the treatment of refractory depression and its influence on the quality of life. Methods 97 patients with refractory depression were selected.According to the random number table, they were divided into the observation group(50 cases) and the control group(47 cases). The control group was given venlafaxine combined with risperidone treatment, the observation group received psychological intervention on basis of the control group.The Hamilton depression scale(HAMD) of patients in the two groups before treatment, 4, 8 and 12 weeks after treatment were recorded.The curative effect after 12 weeks of treatment was evaluated, the adverse reaction was evaluated by the side effects scale(TESS), and the quality of life (WHOQOL-100) of the two groups before treatment, 12 weeks after treatment were compared. Results The HAMD score of the two groups had no statistically significant difference before treatment(t=0.307, P>0.05). After treatment for 4, 8, 12 weeks, the HAMD scores of the two groups were significantly lower than before treatment(t=5.743, 17.756, 27.288, 4.595, 15.801, 23.247, all P 0.05). The WHOQOL-100 scores of the two groups had no statistically significant differences before treatment(t=0.597, 0.497, 0.378, 0.923, 0.136, all P>0.05). The WHOQOL-100 scores of the two groups after treatment were significantly higher than those before treatment(t=11.668, 8.701, 6.857, 7.053, 2.247, 4.815, 4.639, 2.999, 4.117, 2.011, all P<0.05). After treatment, the psychological and physiological independence and social relationship domain scores in the observation group were significantly higher than those in the control group(t=5.618, 3.295, 4.335, 3.603, all P<0.05). Conclusion Psychological intervention combined with venlafaxine and risperidone in the treatment of refractory depression can significantly improve the clinical efficacy, improve the clinical symptoms and the quality of life of patients. Key words: Depressive disorder; Psychotherapy; Venlafaxine; Risperidone; Quality of life