EFFECT OF POLYMORPHIC VARIANTS OF AGT2R1 GENE ON HEMODYNAMIC PARAMETERS IN PREMATURE CHILDREN

Abstract

Relevance. Maintaining hemodynamic in premature infants who are being treated in intensive care units is one of the significant challenges in the practice of modern neonatologists and intensivists. The study of AGT2R1 gene polymorphism can help predict the course of organ dysfunction and prevent the development of adverse clinical consequences.
 The aim is to study the effect of AGT2R1 gene polymorphism on hemodynamic parameters in premature children with bacterial infections.
 Subjects and methods. A prospective cohort study included 143 prematurely born children with bacterial infections: main groups (n=40) had arterial hypotension, control group (n=103) had no arterial hypotension. All patients underwent a standard complex of clinical and laboratory research methods and PCR in order to investigate the A1166C polymorphism of the AGT2R1 gene.
 Results. The study has revealed that the CC genotype of AGT2R1 occur significantly more often in premature children with arterial hypotension than in the control group (OR 10.17, p=0.027). As a result of intragroup analysis among the infants with arterial hypotension, stratified according to polymorphic variants of the AGT2R1 gene, we did not find any significant differences in medico-demographic indicators, the frequency of resuscitation measures, hemodynamic indicators. However, prematurely born children with AC+CC genotype compared to carriers of the AA variant genotype had a lower cardiac index (4.5 vs. 3.5 ml/min*m2, p=0.04), which indicates the influence of myocardial dysfunction on the occurrence arterial hypotension
 Conclusion. A1168C polymorphism of the AGT2R1 gene affects the hemodynamic disorders in premature children with bacterial infections. Further multifaceted studies on a larger sample of patients are required to confirm this hypothesis.