Abstract
The objective of this study is to evaluate the potential toxic effects of an improved A-silicone impression material with decorative properties on the organs and mucous membranes of laboratory animals. Materials and Methods The experiment was conducted on white laboratory rats aged 9 months and weighing 230–285 g. Findings indicate that prolonged contact (30 days) with the material does not result in significant changes in the function of major organ systems in these laboratory rats. Results. A single exposure of laboratory rats to A-silicone impression material with disinfectant properties did not cause significant changes in the physiological state of the animals. Weights of internal organs, including the liver, spleen, heart, and adrenal glands, remained within normal limits, indicating that the material had no toxic effects. The analysis of the peripheral blood composition did not reveal any abnormalities in the number of red blood cells, leukocytes, hemoglobin and other cellular components. The functional state of the liver and kidneys, including the activity of the enzymes AlаT and AсаT, levels of total protein, albumin, creatinine and urea, remained stable and did not change under the influence of the material. There was also no effect on carbohydrate metabolism. No abnormalities in protein synthesis and nitrogen excretion functions were detected, which confirms the safety of the material during the 30-day observation. Conclusion. It was established that this material in the tested dose does not affect the enzyme-synthetic function of the liver and does not exhibit cytolytic effects. The material was found to have no toxic impact on liver function with prolonged use, nor does it cause statistically significant deviations in the measured indicators between the control and experimental groups. The absence of sugar, ketones, and protein in the urine indicates no adverse effect on the renal nitrogen-excreting and saluretic functions, as well as on the vital organs of the rats.
Published Version
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