Abstract
Objective To study the effect of peroxisome proliferator activated receptor2 (PPARγ2) on the proliferation and differentiation of osteoblasts. MethodsAfter cell culturing, identify the cells by ALP staining and mineralized nodules. Methyl thiazol tetrazolium (MTT) assay and PNPP assay were used to observe the effects of PPARγ2 on proliferation and differentiation of the cell. Results Rosiglitazone doesn't effect osteoblasts proliferation (F =1. 335 ,P ＞0. 05) but it could inhibit osteoblasts differentiation. ALP activity in osteoblasts were inhibited differently at the different concentrations of Rosiglitazone ( F =82. 304, P ＜ 0. 01 ). Conclusion Rosiglitazone may inhibit bone formation in a direct fashion by induction of differentiation of osteoblasts. Key words: Peroxisome proliferator activated receptorγ2 ; Rosiglitazone; Osteoblasts; Proliferation; Differentiation
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