Effect of Panax NotoginSeng Saponins on motor evoked potentials of spinal cord injured rats with motion function

Abstract

To investigate the effect of Panax NotoginSeng Saponins(PNS) on functional recovery of rats with spinal cord injury (SCI) after exercise. SD normal rats were randomly divided into normal control group (Normal) and control group (Sham), spinal cord injury (SCI) and spinal cord injury (SCI) + panax notoginseng saponins group (PNS) (n=8). All rats were given basso beattie bresnahan motor function score (BBB) and motor evoked potentials (MEP) examination to observe rat hind limb motor function recovery before operation and 1,3,7,14,21,28 days after operation. After operation, the BBB scores of Sham group, PNS group, SCI group were lower than that of normal; MEP amplitude was lower than that of normal group; the incubation time was prolonged compared with that in normal group. In PNS group compared with that in the SCI group, BBB scores at 7,14,21 and 28 days was significantly different(P<0.05). There were significant differences in the latency (Lat) and amplitude(Amp) of MEP within PNA subgroups or between the PNS and the SCI groups at 7,14,21,28 days(P<0.05). PNS can promote the recovery of motor function after SCI in rats.