Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

Peter Eickholz,Martin Wohlfeil,Gerhard M Oremek,Mario Schröder,Beate Schacher,Anne Asendorf,Luigi Nibali,Frank Kaiser

doi:10.1007/s00784-020-03292-7

Peter Eickholz, Martin Wohlfeil + Show 6 more

Open Access

PDF Available

https://doi.org/10.1007/s00784-020-03292-7

Copy DOI

Export

Save

Cite

Abstract
Highlights/Summary
Full-Text PDF
Similar Papers

Abstract

Listen

AimAssessment of the effect of nonsurgical periodontal therapy on haematological parameters in patients with grades B (BP) and C periodontitis (CP).MethodsEight BP and 46 CP patients received full-mouth periodontal debridement within 48 h, if positive for Aggregatibacter actinomycetemcomitans with adjunctive systemic antibiotics (4 BP, 17 CP). Clinical data were collected prior and 12 weeks after periodontal therapy. Blood was sampled prior to and 1 day as well as 6 and 12 weeks after the first SD visit. Erythrocyte count, haemoglobin value, haematocrit (HCT), mean erythrocyte volume (MCV), mean corpuscular haemoglobin (MCH), MCH concentration (MCHC), platelets (PLT) and heat shock protein 27 (Hsp27) were assessed.ResultsBoth groups showed significant clinical improvement (p < 0.05). Using univariate analysis, MCV was noticeably lower in CP than BP at all examinations, HCT only at baseline. For CP, MCHC was noticeably higher 12 weeks after SD than at baseline and 1 day (p ≤ 0.005) and Hsp27 increased noticeably at 1 day (p < 0.05). Repeated measures analysis of variance revealed African origin to be associated with lower MCV and female sex with lower MCHC.ConclusionBased on multivariate analysis, periodontal diagnosis (BP/CP) was not associated with haematological parameters measured in this study or serum Hsp27. In CP, nonsurgical periodontal therapy improved MCHC 12 weeks after SD. Also in CP Hsp27 was increased 1 day after SD.

Highlights

Depending on individual predisposition and modifying factors, periodontitis is initiated at different ages and progresses at different speeds in different patients
aggressive periodontitis (AgP) and periodontitis grade C exhibit more rapid progression. This may be due to a hyperinflammatory phenotype that may be detected in the serum by a higher inflammatory burden (i.e. C-reactive protein [CRP] and neutrophil elastase [NE]) as shown for AgP [3,4,5]
Thirty-one ChP and 29 AgP patients were enrolled between October 2006 and December 2009

Summary

Introduction

Depending on individual predisposition and modifying factors, periodontitis is initiated at different ages and progresses at different speeds in different patients. AgP and periodontitis grade C exhibit more rapid progression. This may be due to a hyperinflammatory phenotype that may be detected in the serum by a higher inflammatory burden (i.e. C-reactive protein [CRP] and neutrophil elastase [NE]) as shown for AgP [3,4,5]. Extracellular cell stress proteins have the capacity to control inflammatory response and as such have been proposed as useful biomarkers e.g. heat shock protein 27 (Hsp27) to indicate anti-inflammatory activity [6]. The myeloid cell– modulating cell stress protein Hsp has been described to exert anti-inflammatory activities [7, 8]. Patients suffering from AgP have been shown to exhibit lower serum levels of Hsp than ChP patients and periodontally healthy controls [9]. Periodontal treatment has previously been shown to increase the plasma level of Hsp10 [10]

Methods

Results

Conclusion