Abstract
Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, high-sensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.
Highlights
Periodontal disease is an immunoinflammatory disease of infectious etiology, including gingivitis and periodontitis, which affect the protective and supporting tissues of teeth.[1]
Evidence indicates that nonsurgical periodontal therapy (NSPT) might influence the development of cardiovascular disease,[8] rheumatoid arthritis,[9] type 1 diabetes mellitus,[10] respiratory disease,[11] and chronic kidney disease.[12]
Study design and groups This was an interventional study performed on individuals awaiting care in the outpatient clinics of the Dental School at the Federal University of Maranhão (UFMA), São Luís, Maranhão, Brazil
Summary
Periodontal disease is an immunoinflammatory disease of infectious etiology, including gingivitis and periodontitis, which affect the protective and supporting tissues of teeth.[1]. These inflammatory mediators cause bone loss and destruction of the extracellular matrix in the gingiva and stimulate the production of acute phase proteins, with IL-6 being recognized as the main inductor.[3,4,5]. The low intensity of the chronic inflammatory process in periodontitis has been suggested as a mechanism that determines the biological plausibility in periodontitis and other systemic diseases.[6,7] evidence indicates that nonsurgical periodontal therapy (NSPT) might influence the development of cardiovascular disease,[8] rheumatoid arthritis,[9] type 1 diabetes mellitus,[10] respiratory disease,[11] and chronic kidney disease.[12]
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