Effect of non-surgical treatment of negative pressure wound therapy combined with pig degenerative dermal matrix dressing on the repair of limb deep burn wounds

Abstract

Objective To analyze the clinical efficacy of negative pressure wound therapy(NPWT)combined with pig decellularized dermal matrix(ADM)on the repair of limb deep burn wound. Methods From March 21, 2015 to January 18, 2016, 102 patients with limb deep burn wounds in the Affiliated Hospital of Binzhou Medical College were selected, and randomly divided into conventional group and observation group, with 51 cases in cach group.The conventional group was treated with ADM dressing alone, and NPWT + ADM was used in the experimental group.The therapeutic effect was compared between the two groups. Results The drainage fluid volume after treatment for 21d in the observation group was(18.65±1.23)mL, which was significantly less than that in the conventional group[(48.36±3.12)mL, t=63.265, P=0.000]. The wound healing rates of the observation group after treatment for 7d(t=153.829, P=0.000), 14d(t=53.786, P=0.000), 21d(t=70.763, P=0.000)were significantly higher than those of the conventional group.The wound healing time of the observation group[(18.86±1.52)d]was significantly shorter than the conventional group[(28.32±1.76)d, t=29.050, P=0.000]. Conclusion For patients with limb deep burn wounds, NPWT combined with ADM treatment has remarkable effect, can obviously improve the clinical symptoms, promote disease recovery, it is worthy of popularizing. Key words: Burns; Negative pressure wound therapy; Pig decellularized dermal matrix