Abstract
Objective: The study aims to investigate the effect of acute noise stress on cognitive functions in male Wistar albino rats.
 Methods: Adult albino rats were randomly divided into two groups. Each group contains six animals. Rats exposed to acute noise stress (100 dB/4 h) were compared with control animal and assessed for cognition using T-maze, hole-board test, open-field test, marble burying test, and social interaction behavior.
 Results: The rats exposed to acute noise stress showed the significance (p<0.05) of behavioral alterations such as impaired learning and memory, memory retention, increased fear and anxiety, obsessive–compulsive behavior, social avoidance, and decreased social interaction.
 Conclusion: The results report that acute noise stress affects the cognition, and it became chronic may confer the increased risk of neurodegenerative disorders.
Highlights
Stress is an unavoidable circumstance in our life
Stress responses evolved as adaptive processes, Selye observed that severe, prolonged stress responses might lead to tissue damage and disease [16]
Stress initiates a series of neuronal responses and can lead to the development of behavioral disorders associated with cognitive impairments, depression, and anxiety [16]
Summary
Noise is gradually becoming the most pervasive environmental and occupational stress pollutant in a modern era [1]. Noise has been defined as unwanted sound. It consists of unpleasant obtrusive annoying, distracting, or persistent sounds that interfere with sleep or the ability to concentrate or enjoy life [4]. The damaging effects of noise are not limited to the auditory system but rather extend too many other systems. Acute and chronic loud noise exposure generates excessive free radicals and causes disorders involving extra-auditory organs such as nervous, endocrine, and cardiovascular systems [7]. Neural tissue is very sensitive to oxidative stress due to the brain cells are more vulnerable to free radical damage caused by lipid peroxidation compared to other tissues, owing to their high level of unsaturated fatty acids [8]. It is planned to study the effect of acute noise on cognition in a noise-induced animal model
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