Abstract
The effect of muscular exercise (physical training) on gluconeogenesis in rat kidney cortex has been reported by Krebs [ 11. Forced exercise (swimming) increases the gluconeogenic capacity of the kidney, almost as much as a low-carbohydrate diet. On the other hand, Yakovlev has found an increase in the activity of rat liver glucose-Gphosphatase in similar conditions [2]. The well established key role of phosphoenolpyruvate carboxykinase (PEPCK) in gluconeogenesis and its sensitivity to hormonal treatment or starvation in liver and kidney 13-71 prompted us to investigate the effect of exercise on this enzyme.
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