Effect of MoS2 on Simple and Novel PEG/κ-Carrageenan Hydrogels for TNBC Cancer Drug Delivery

Abstract

Molybdenum disulfide (MoS2), a two-dimensional inorganic molecule, has lately been studied in medical research with regard to carrying pharmaceuticals due to its distinctive characteristics. A biodegradable polymer system applicable in cancer drug delivery can be created with the addition of MoS2. In our research described in this paper, we investigated the influence of the amount of MoS2 on the characteristics and performance of our novel gel blend. It was aimed to prepare a new gel blend, which we thought would have the potential to be used as a stimulus-sensitive, polymeric hydrogel as a carrier in the triple negative breast cancer (TNBC) drug delivery system, with the MoS2 added to the polyethylene glycol (PEG)/κ-carrageenan combination. This 2D material (MoS2) impacted the hydrogel by improving the transmittance, swelling, and elasticity performance compared to the normal no MoS2 structure of the polymeric gel. The polymer blend characteristics were mainly tested using UV-VIS spectrophotometry and gravimetric analysis. The varied properties of these gel mixtures were investigated using five different mass ratios of MoS2. The 5 mg MoS2/(PEG)/κ-carrageenan gel was the best sample investigated in terms of the elasticity. The results of the study demonstrated that our gel system can be utilized for precisely targeted and regulated delivery of cancer drugs. To create preliminary data for this near future goal, the release mechanism of the Doxorubicin drug loaded into the produced gel were examined.