Abstract
Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer detection and drug delivery systems by modifying AS1411 aptamers based on graphene, mesoporous silica, silver and gold. The application of AS1411 in cancer treatment and drug delivery and the use of AS1411 as a targeting agent for the detection of cancer markers such as nucleoli were summarized from three aspects of active targeting, passive targeting and targeted nucleic acid apharmers. Although AS1411 has been withdrawn from clinical trials, the research surrounding its structural optimization is still very popular. Further progress has been made in the modification of nanoparticles loaded with TCM extracts by AS1411.Graphical
Highlights
Cancer is a kind of disease caused by abnormal cell proliferation in the body
We describe the effects of AS1411 on cell migration, cell proliferation, and miR-21 and miR-221 expression of human limbal stromal cells treated with vascular endothelial growth factor (VEGF)
It can bind to the nuclear protein on the surface of cancer cells and inhibit the NF-κB pathway
Summary
Introduction Cancer is a kind of disease caused by abnormal cell proliferation in the body. In order to target site-specific colorectal cancer cells with overexpressed nucleoprotein receptors, this dendritic molecule was functionalized with AS1411 anti-nucleoprotein aptamer with the goal of inhibiting C26 tumor growth in vivo and significantly reducing systemic toxicity. Farnaz Sadat Mirzazadeh Tekie group reported the preparation of the resistance with nucleoli [191] suitable body AS1411 modified TD-miR(redox-responsive miR-145 conjugated thiolated dextran) and chitosan polyelectrolyte complexes, used to enhance the cancer cells to absorb nanoparticles, including targeted agent for attached AS1411 suitable body nucleolus resistance element This method has higher gene silencing and apoptosis than previous methods. The main principle of hydrogel formation is that AS1411 initiates the hybridization of acid-modified oligonucleotides, leading to gel dissolution in the presence of the target protein nucleoprotein Such aptam-functionalized hydrogels can be used for targeted cancer cell recognition and targeted drug delivery.
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