Abstract
Objective To investigate the effect of morphine combined with noninvasive positive pressure ventilation in the treatment of patients with acute left heart failure. Methods 80 patients with acute left heart failure were enrolled, and they were randomly divided into two groups according to the digital table method, 40 cases in each group.The patients in the control group were treated with noninvasive positive pressure mechanical ventilation.The patients in the observation group were treated with morphine sedation on the basis of the treatment of the control gorup.The vital signs test indicators, disease-related parameters, clinical events, cognitive function and quality of life were compared between the the two groups. Results The systolic blood pressure, heart rate, respiratory rate, PaCO2 and myocardial oxygen consumption in the observation group were significantly lower than those in the control group at 30min after treatment, PaO2 and pH in the observation group were significantly higher than those in the control group, the APACHEⅡ, BNP, Hs-cTnl and CK levels in the observation group at 24 h after treatment were significantly lower than those in the control group, the differences were statistically significant(t=8.349, 13.127, 7.413, 17.072, 15.334, 2.631, 3.088, 12.371, 8.061, 4.784, 18.931, 6.568, 9.464, all P 0.05]. Conclusion Morphine has significant influence on the effect of noninvasive positive pressure mechanical ventilation in patients with acute left heart failure. Key words: Heart failure; Ventilators, mechanical; Positive-pressure respiration; Morphine; Quality of life
Published Version
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