Abstract
Objective: To determine the possible effects of aqeous extract of Moringa oleifera on blood glucose and lipid profile in alloxan induced diabetic albino rats. Materials and Methods: Forty four (44) adult healthy Albino rats of both sexes divided into three groups (A=23, B=10 and C=11)were used for this study; they were kept under standard conditions in the Animal House of the Department of Biomedical Sciences of Ladoke Akintola University of Technology, Osogbo, Nigeria. Diabetes mellitus was induced in rats in groups A and B with 5-day of alloxan administered intraperitoneally. Only rats in group A were given aqueous extracts of Moringa oleifera for a period of nine days. Body weight and fasting blood glucose were checked at 5 th and 14 th day of the experiment. Parameters of lipid profile were determined in rats at day 14. Results: Average fasting blood sugar for groups A, B and C were observed to be 10.10mmol/l, 9.84mmol/l and 4.23mmol/l respectively at day 5. There was a reduction in fasting blood glucose in rats in groups A and C while there was an increase in fasting blood glucose in rats in group B when checked at day 14. Rats in group B (alloxan induced DM without Moringa oleifera supplement) had lowest value of HDL-Chol while their values of LDL-Chol, TC-Chol and Tg were the highest. There was significant lower value of HDL-Chol in group B than rats in Group A (p<0.05) and rats in group C (p<0,05). Conclusion: There was a hypoglycaemic effect of the aqueous extract of Moringa oleifera. It also has capacity to ameliorate dyslipidaemia in diabetic rats.
Highlights
It has been estimated that about 285 million people in the world were suffering from Diabetes Mellitus (DM) as at 2010 and more than 438 million victims are assumed to be having the disease by the year 2030.1 Diabetes Mellitus is described as a metabolic disorder characterized by hyperglycaemia that may be as a result of inadequate insulin production or insensitivity of body cells to respond to insulin action, or both
Patients still come down with complications like dyslipideamia[5]. This is one of the reasons why fasting plasma lipid profile is recommended in the course of management of Diabetes Mellitus[5]
The plasma samples collected from the rats were used for the laboratory analysis of full lipid profile while the fasting blood glucose (FBG) of rats was measured from capillary sample gotten at the tail snips of those rats
Summary
It has been estimated that about 285 million people in the world were suffering from Diabetes Mellitus (DM) as at 2010 and more than 438 million victims are assumed to be having the disease by the year 2030.1 Diabetes Mellitus is described as a metabolic disorder characterized by hyperglycaemia that may be as a result of inadequate insulin production or insensitivity of body cells to respond to insulin action, or both. This results into the disturbance of carbohydrate metabolism and fat and protein metabolisms[2]. This work seeks to evaluate the possible blood sugar lowering and lipid adjustment effects of the aqueous extracts of Moringa oleifera in the alloxan induced diabetic albino rats
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