Effect of montelukast sodium on TGF- 1 level of peripheral blood mononuclear cells from children with mild persistent asthma

Abstract

Objective To explore the effect and mechanism of montelukast sodium on transforming growth factorβ1 (TGF-β1) expression in children with asthma. Methods 80 children with asthma were divided into 2 groups.The control group was treated with common medicine, and the observation group was treated with montelukast sodium.The clinical effect of two groups was evaluated.The peripheral eosinophile granulocyte(EOS) count of children was measured before and after treatment.Double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) was used to detect the serum levels of TGF-β1 and leukotriene E4 (LTE4) before and after treatment. Results The total effective rate of montelukast sodium group was 95.0%, remarkable effect in 28 cases, 10 cases were effective, and 2 cases failed.The total effective rate of the control group was 82.5%, 23 cases had remarkable effect, effective in 10 cases, ineffective in 7 cases.The effective rate of the montelukast sodium group was statistically higher than the control group(χ2=4.200, P 0.05). After treatment, the levels of serum TGF- 1, LTE4 of the observation group decreased more remarkably when compared with the control group (TGF-β1: t=2.06, P<0.05; LTE4: t=2.14, P<0.05). Conclusion Montelukast sodium has good clinical effect on childhood asthma.It can inhibit the expression of TGF- 1 in childhood asthma, and its mechanism may be related to eosinophils and the level of LTE4. Key words: Asthma; Growth factor beta 1; Montelukast sodium; Child