Effect of microsurgical clearance combined with vacuum sealing drainage for chronic osteomyelitis

Abstract

Objective To explore the clinical effect of microsurgical clearance combined with vacuum sealing drainage(VSD) for chronic osteomyelitis, and to analyze its complications. Methods 80 patients with chronic osteomyelitis in the People's Hospital of Xuecheng District from January 2014 to January 2015 were selected and randomly divided into two groups according to the digital table, with 40 cases in each group.The observation group was treated with microsurgical clearance combined with VSD, the control group was given microsurgical clearance treatment.The changes of inflammatory factors were compared at 1 week after treatment, and the number of wound dressing, the percentage of wound healing and the time of clinical healing were analyzed. Results After treatment for 1 week, the levels of tumor necrosis factor-α(TNF-α), interleukin-1(IL-1) and high-sensitivity C-reactive protein(hs-CRP) in the observation group were (12.0±0.1)μg/L, (0.6±0.1)μg/L, (10.7±1.0)mg/L, respectively, which were significantly lower than those in the control group [(18.5±0.6) μg/L, (0.9±0.2)μg/L, (31.2±2.0) mg/L](t=67.584, 9.899, 57.983, all P<0.05). The number of dressing in the observation group was less than that in the control group[(7.4±1.2) times vs.(7.3±1.2) times, t=16.499, P<0.05)]. The recovery rate of the wound in the observation group was higher than that in the control group[(47.4±2.9)% vs.(16.4±1.2)%, t=62.470, P<0.05]. The clinical healing time in the observation group was shorter than that in the control group[(25.3±1.8)d vs.(33.2±2.7)d, t=15.397, P<0.05)]. The incidence rate of complications such as infection, hematoma and wound unhealing in the observation group was 7.5%, which was lower than 35.0% in the control group (χ2=7.470, P<0.05). Conclusion Microsurgical treatment combined with VSD in the treatment of patients with chronic osteomyelitis can effectively reduce the inflammatory reaction, so it can promote wound healing and reduce related complications. Key words: Osteomyelitis; Microsurgery; Drainage; Negative-pressure wound therapy