Abstract
Vernonia amygdalina is a shrub that grows throughout tropical Africa. Several studies have reported the nutritional, anti-malaria and anti-helminthic effects of its extracts; but there is a dearth of information on its effect on blood chemistry. This study was designed to investigate the effect of methanolic extract of Vernonia amygdalina (MEVA) on the haematological and plasma biochemical parameters in male albino rats. Treatment of rats for 30 days with all the treatment doses (50 mg/kg BW, 100 mg/kg BW, 150 mg/kg BW) of MEVA caused no significant (p>0.05) changes in all the haematological parameters (PCV, RBC, TWBC, Hb, MCHC, MCH, MCV, platelet, neutrophil, lymphocyte, eosinophil, monocyte) values relative to their respective controls. However, treatment of rats with 100 mg/kg BW and 150 mg/kg BW of MEVA caused significant (p<0.05) increase in albumen levels relative to the control. But treatment of rats with all the treatment doses of MEVA caused significant (p<0.05) decreased in ALT levels relative to the control. These findings suggest that methanolic extract of Vernonia amygdalina have beneficial potentialities on the blood of male albino rats.
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